2011 Fiscal Year Final Research Report
Structural biology of polyubuiquitin chain recognition
| Project/Area Number |
21687009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUKAI Shuya 東京大学, 放射光連携研究機構, 准教授 (10361792)
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| Project Period (FY) |
2009 – 2011
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| Keywords | X線結晶構造解析 / ユビキチン / 分子間相互作用 / 炎症シグナル / DNA損傷応答 |
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| Research Abstract |
Ubiquitin is well-known as a label for protein degradation. Recent studies have showed that ubiquitin functions as labels for various cellular processes besides the protein degradation. In this research, we determined three-dimensional structures of complexes comprising ubiquitin and its binding proteins and showed how ubiquitin is recognized during responses towards DNA damage and inflammation.
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[Journal Article] Specific recognition of linear ubiquitin chains by the Npl4 zinc finger(NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex2011
Author(s)
Sato, Y., Fujita, H., Yoshikawa, A., Yamashita, M., Yamagata, A., Kaiser, S. E., Iwai, K., Fukai, S
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Journal Title
Proceedings of National Academy of Science United States of America
Volume: 108巻
Pages: 20520-20525
DOI
Peer Reviewed
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[Journal Article] Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin2009
Author(s)
Yoshikawa, A., Sato, Y., Yamashita, M., Mimura, H., Yamagata, A., Fukai, S.
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Journal Title
FEBS Letters.
Volume: 583巻
Pages: 3317-3322
DOI
Peer Reviewed
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[Journal Article] Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP802009
Author(s)
Sato, Y., Yoshikawa, A., Mimura, H., Yamashita, M., Yamagata, A., Fukai, S.
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Journal Title
The EMBO Journal
Volume: 28巻
Pages: 2461-2468
DOI
Peer Reviewed
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