2012 Fiscal Year Final Research Report
Role of caveolae and caveolinin postconditioning-induced cardiac protection
Project/Area Number |
21689042
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | The University of Tokushima |
Principal Investigator |
TSUTSUMI Yasuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (90523499)
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Project Period (FY) |
2009 – 2012
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Keywords | 麻酔学 / 心筋虚血再灌流障害 |
Research Abstract |
Caveolae are small, flask-like invaginations of the plasma membrane. Caveolins are structural proteins found in caveolae that have scaffolding properties to allow organization of signaling. The authors tested the hypothesis that cardiac protection induced by postconditioning is caveolae or caveolin dependent.
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[Journal Article] Ingrid R. Niesman, Timo Rieg, Volker Vallon, Paul A. Insel, Hemal H. Patel, and David M. RothCardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling.2011
Author(s)
Yousuke T. Horikawa, Mathivadhani Panneerselvam, Yoshitaka Kawaraguchi, Yasuo Tsutsumi, Sameh S. Ali, Ravi C. Balijepalli, Fiona Murray, Brian P
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Journal Title
J Am Coll Cardiol
Volume: 57
Pages: 2273-2283
DOI
Peer Reviewed
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