2011 Fiscal Year Final Research Report
Extension of the MAFFT algorithm to RNA and protein structural multiple alignment
| Project/Area Number |
21700326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | National Institute of Advanced Industrial Science and Technology (2010-2011)
Kyushu University (2009) |
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Principal Investigator |
KATOH Kazutaka 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 招聘研究員 (70378868)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 配列アラインメント / 構造アライメント / タンパク質 / 並列計算 / バイオインフォマティクス |
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| Research Abstract |
Alignment of multiple sequences is a basic technique for sequence analysis, and has various applications, including phylogenetic inference and structure prediction. This research aims(1) to extend the MAFFT multiple sequence alignment program to enable structural alignment of proteins and RNAs, and(2) to enhance its usability to contribute to a wide range of studies that use biological sequences. We started a new web services for alignment calculation and distribution of the program in CBRC, AIST and Osaka University. As a result the MAFFT program has gained worldwide popularity. We also have implemented several new features, such as parallelization, and the addition of new sequences into an existing alignment.
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