2010 Fiscal Year Final Research Report
A novel mechanism of dendritic spine formation by synapse-resident transcriptional coactivator
| Project/Area Number |
21700340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University |
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Principal Investigator |
YAMAZAKI Hiroyuki Gunma University, 大学院・医学系研究科, 助教 (10334137)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 樹状突起スパイン / 樹状突起フィロポディア / 転写調節因子 |
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| Research Abstract |
In this study, we analyzed the role of SPIKAR, a novel transcriptional-coactivator, in dendritic spine formation. SPIKAR is localized in not only nucleus but also cytoplasm. We indicated that SPIKAR is involved in early phase of spine formation, especially in filopodia formation. SPIKAR-Knockout mice showed embryonic fatality, suggesting that SPIKAR has pivotal roles in ontogenesis as well as neuronal development.
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[Journal Article] F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse.2010
Author(s)
Perez-Martinez M, Gordon-Alonso M, Cabrero JR, Barrero-Villar M, Rey M, Mittelbrunn M, Lamana A, Morlino G, Calabia C, Yamazaki H, Shirao T, Vazquez J, Gonzalez-Amaro R, Veiga E, Sanchez-Madrid F.
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Journal Title
J Cell Sci. 123
Pages: 1160-1170
Peer Reviewed
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[Journal Article] Chemico-genetic identification of drebrin as a regulator of calcium responses.2010
Author(s)
Mercer JC, Qi Q, Mottram LF, Law M, Bruce D, Iyer A, Morales JL, Yamazaki H, Shirao T, Peterson BR, August A.
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Journal Title
Int J Biochem Cell Biol. 42
Pages: 337-345
Peer Reviewed
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