Analysis of O-glycosylated α-synuclein

2010 Fiscal Year Final Research Report

• Project/Area Number: 21700395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Juntendo University
• Principal Investigator: SHIMURA Hideki Juntendo University, 医学部, 准教授 (50286746)
• Project Period (FY): 2009 – 2010
• Keywords: パーキンソン病 / O結合型糖化αシヌクレイン

Research Abstract

We investigated O-glycosylatedα-synuclein by biochemical analysis. We identified NeuNAcα2-3Galβ1-3GalNAcαattached to 33Thr, 44Thr, 54Thr residues ofα-synuclein.

Research Products

• [Journal Article] A case of cerebral embolism with metastatic chondrosarcoma in the left atrium. (2011)
  • Author(s): Oizumi H, Tanaka R, Shimura H, Sasaki K, Koike H, Hattori N, Tanaka S.
  • Journal Title: J Stroke Cerebrovasc Dis. 20(1) Pages: 79-81
• [Journal Article] Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. (2010)
  • Author(s): Miyamoto N, Tanaka R, Shimura H, Watanabe T, Mori H, Onodera M, Mochizuki H,Hattori N, Urabe T.
  • Journal Title: J Cereb Blood Flow Metab. 30(2) Pages: 299-310
• [Journal Article] Predominant Vasogenic Edema in a Patient with Fatal Cerebral Air Embolism. (2010)
  • Author(s): Tanaka R, Shimada Y, Shimura H, Oizumi H, Hattori N, Tanaka S.
  • Journal Title: J Stroke Cerebrovasc Dis.
• [Journal Article] Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. (2010)
  • Author(s): Kawanabe T, Yoritaka A, Shimura H, Oizumi H, Tanaka S, Hattori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34(2) Pages: 284-287
• [Journal Article] Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. (2010)
  • Author(s): Miyamoto N, Tanaka R, Shimura H, Watanabe T, Mori H, Onodera M, Mochizuki H, Hattori N, Urabe T.
  • Journal Title: J Cereb Blood Flow Metab. 30(2) Pages: 299-310
• [Journal Article] Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. (2009)
  • Author(s): Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N.
  • Journal Title: FEBS Lett. 583(13) Pages: 2194-2200
• [Journal Article] Crucial role for Ser133-phosphorylated form of cyclic AMP-responsiveelement binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion. (2009)
  • Author(s): Miyamoto N, Tanaka R, Zhang N, Shimura H, Onodera M, Mochizuki H, Hattori N, Urabe T.
  • Journal Title: Neuroscience. 162(2) Pages: 525-536
• [Journal Article] Economy Class Stroke Syndrome after a Long Drive.
  • Author(s): Tanaka R, Kawanabe T, Yamauchi Y, Shimura H, Tanaka Y, Miyamoto N, Ueno Y,Urabe T, Hattori N, Tanaka S.
  • Journal Title: J Stroke Cerebrovasc Dis. 2010
• [Presentation] O-結合型糖化α-synucleinの生化学的解 (2010)
  • Author(s): 志村秀樹、佐々木久美、Schlossmacher Michael、Selkoe Dennis、服部信考
  • Organizer: 日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100000
• [Remarks] ホームページ等