2010 Fiscal Year Final Research Report
Fundamental Study for Development of An Engineering Model of Remodeling Mechanism of Blood Vessel Walls in Response to Mechanical Environment
| Project/Area Number |
21700457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKAMOTO Naoya Tohoku University, 大学院・工学研究科, 助教 (20361115)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生体システム・フィジオーム / 細胞・組織 / 力学刺激 / リモデリング / 血管内皮細胞 / 細胞外基質分解酵素 |
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| Research Abstract |
To understand quantitative relationship between hemodynamic environment and remodeling of vessel walls, I investigated functional changes in vascular endothelial cells (ECs) exposed to fluid shear stress conditions. The results indicate that EC activity in wall degradation is suppressed under a physiological shear stress condition and higher shear stress may enhance the activity in degradation of vessel walls. Furthermore, I found that spatial gradient of shear stress also has an impact on ECs functions, which may be crucial to formation of vascular diseases.
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