2010 Fiscal Year Final Research Report
Clarification of molecular mechanism of pressure ulcers and approach on prevention by physical therapy
| Project/Area Number |
21700533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hiroshima University |
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Principal Investigator |
KUROSE Tomoyuki Hiroshima University, 大学院・保健学研究科, 助教 (20363054)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 褥瘡 / リアルタイムPCR / 酸化ストレス |
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| Research Abstract |
NF-kB, HIF-la, and NOS (nNOS, iNOS, nNOS) that causes an oxidant stress were examined with Real-Time PCR. Only iNOS has increased remarkably. If the oxidant stress is controlled by obstructing iNOS, the generation of the pressure ulcers might be suppressed.
For a clinical pressure ulcers model by whom pressure is repeated, the proinflammatory cytokines have increased more than application of single pressure. I think further of importance of the proinflammatory cytokine if it proves.
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