2010 Fiscal Year Final Research Report

Analysis of brain-protein profiles involved in the brain function which is preserved and enhanced by muscle activity.

Research Project

Project/Area Number	21700655
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Sports science
Research Institution	Osaka University
Principal Investigator	OKE Yoshihiko Osaka University, 医学系研究科, 助教 (50396470)
Project Period (FY)	2009 – 2010
Keywords	運動とトレーニング / プロテオミクス
Research Abstract	It is common knowledge that exercise, especially muscle activities of inferior limbs, can have an adverse effect on cognitive function of the brain. In this research, I investigated effects of muscle activities on cellular or molecular mechanism involved in maintaining and progress of the brain function. In order to inhibit the antigravitational muscle activities, I used hindlimb-suspended rats. The results from water maze test suggest that learning and memory capacity might be impaired by the hindlimb suspension. Furthermore, 2-dementional electrophoresis revealed that the hindlimb suspension could alter the protein expression levels and/or the modification of proteins in the hippocampus, involved in cellular protection, cell death, neurogenesis, neural activities and formation of the neuronal circuit.