2011 Fiscal Year Final Research Report
Effect of plant polyphenols on oxidative stress and lipid metabolism in pregnancy-induced hypertension rat models
| Project/Area Number |
21700760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
MUKAI Yuuka 青森県立保健大学, 健康科学部, 助教 (60331211)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 妊娠高血圧症候群 / アズキポリフェノール / 酸化ストレス / 血液凝固線溶系 / 胎盤 / 胎児 / フルクトース / 脂質代謝 |
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| Research Abstract |
In order to examine the effect of plant polyphenols on maternal blood pressure, oxidative stress, and glucose and lipid metabolism in pregnancy-induced hypertension rat models, pregnant rats were treated by nitric oxide(NO) synthase inhibitor or excess intake of fructose. In NO-deficient pregnant rats, azuki bean polyphenols up-regulated significantly renal expression of Mn-superoxide dismutase, although significant decrease in maternal blood pressure was not observed. In fructose-fed pregnant rats, azuki bean polyphenols partly diminished hepatic expression of lipogenic transcription factor
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Research Products
(14 results)
