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2010 Fiscal Year Final Research Report

Mechanical control of the Brownian process for bio nano-motors

Research Project

  • PDF
Project/Area Number 21710120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionOsaka University

Principal Investigator

IWAKI Mitsuhiro  Osaka University, 医学系研究科, 助教 (30432503)

Project Period (FY) 2009 – 2010
Keywords1分子生理 / 生化学
Research Abstract

I constructed the dark-field microscopy combined with an optical trap for the single molecule measurements. Using this apparatus, I succeeded in both direct observation of Brownian search process in the stepping motion of bio nano-motor, myosin-V and mechanical control of the process. Dwell time analysis, noise analysis for the Brownian process and the load dependency enabled us to model bio nano-motor from a viewpoint of the roll of thermal noise in mechanical function. This is an important result toward control of nano-machine using noise such as stochastic resonance.

  • Research Products

    (15 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Entropic potential field formed for a linear-motor protein near a filament : Statistical-mechanical analyses using simple models2010

    • Author(s)
      K.Amano, T.Yoshidome, M.Iwaki, M.Suzuki, M.Kinoshita
    • Journal Title

      Journal of Chemical Physics Vol.133

      Pages: 045103-1-045103-11

    • Peer Reviewed
  • [Journal Article] Brownian search-and-catch mechanism for myosin-VI steps2009

    • Author(s)
      M.Iwaki, A.Iwane, T.Shimokawa, R.Cooke, T.Yanagida
    • Journal Title

      Nature Chemical Biology Vol.5

      Pages: 403-405

    • Peer Reviewed
  • [Presentation] Brownian search-and-catch mechanism for myosin-VI steps2011

    • Author(s)
      M.Iwaki
    • Organizer
      Gordon research conferences -Stochastic physics in biology-
    • Place of Presentation
      Baltimore, Maryland
    • Year and Date
      20110123-20110129
  • [Presentation] Observation and control of mechanical process in skeletal myosin steps2011

    • Author(s)
      M.Iwaki
    • Organizer
      Workshop on Hydration and ATP energy 2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-16
  • [Presentation] Observation of mechanical process for myosin-II by a dark-field microscopy combined with an optical trap2011

    • Author(s)
      M.Iwaki
    • Organizer
      Biophysical Society 55<th> Annual meeting
    • Place of Presentation
      Baltimore, Maryland
    • Year and Date
      2011-03-05
  • [Presentation] Observation of mechanical process for myosin-II by a dark-field microscopy combined with an optical trap2010

    • Author(s)
      M.Iwaki
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学
    • Year and Date
      20100920-20100922
  • [Presentation] Brownian search-and-catch mechanism for myosin-VI steps2010

    • Author(s)
      M.Iwaki
    • Organizer
      Biophysical society 54th annual meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      20100220-20100224
  • [Presentation] Visualizing and clarifying the mechanical properties of the myosin V Brownian search with optical tweezers2010

    • Author(s)
      M.Iwaki
    • Organizer
      RIKEN QBiC Kick-off meeting
    • Place of Presentation
      OLABB, Osaka
    • Year and Date
      20100126-20100127
  • [Presentation] Brownian search-and-catch mechanism for actomyosin2010

    • Author(s)
      M.Iwaki
    • Organizer
      International symposium on single molecule nano detection and its application to life science
    • Place of Presentation
      淡路夢舞台国際会議センター
    • Year and Date
      2010-04-17
  • [Presentation] Brownian search-and-catch mechanism for myosin VI steps2009

    • Author(s)
      M.Iwaki
    • Organizer
      Watching biomolecules in action symposium
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      20091215-20091217
  • [Presentation] ミオシンVIのストレインセンサーの定量解析2009

    • Author(s)
      岩城光宏
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      徳島文理大学
    • Year and Date
      2009-10-29
  • [Presentation] ナノ粒子を利用したモーター蛋白質の高速1分子ナノイメージングと操作2009

    • Author(s)
      岩城光宏
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-21
  • [Book] 生物物理:ストレインセンサーが制御するミオシンVIのブラウン運動整流機構2010

    • Author(s)
      岩城光宏
    • Total Pages
      88-89
    • Publisher
      日本生物物理学会
  • [Book] Annual Report of Osaka University. Academic Achievement-2009-20102010

    • Author(s)
      Mitsuhiro Iwaki
    • Total Pages
      1
    • Publisher
      大阪大学出版会
  • [Remarks] 岩城光宏、日本経済新聞「筋肉を収縮させる力分子センサーが制御」2009年5月

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Published: 2012-02-13   Modified: 2016-04-21  

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