Identification of the genetic factor against influenza virus infection in the chicken MHC region.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21710204
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied genomics
• Research Institution: National Institute of Genetics (2010); Tokai University (2009)
• Principal Investigator: HOSOMICHI Kazuyoshi National Institute of Genetics, 総合遺伝研究系, 助教 (50420948)
• Project Period (FY): 2009 – 2010
• Keywords: ニワトリ / MHC / ゲノム / 多様性 / SNP / トリインフルエンザ

Research Abstract

The chicken MHC (MHC-B) is one of the research interests because of the strong associations with avian influenza virus infection identified in particular MHC-B haplotypes. Because sequence data of MHC-B haplotypes have been lacking, efforts to systematically resolve which genes within the MHC-B region contribute to well-defined MHC-B-associated disease responses was hampering. To indetify the genetic factor against influenza virus infection in the MHC-B region, we determined the complete genomic sequence of 2 MHC-B haplotypes across a region of 220kb encompassing 34 gene loci ranging from KIFC1 to C4.

Research Products

• [Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele. (2011)
  • Author(s): Mitsunaga S, Okudaira Y, Kunii N, Cui T, Hosomichi K, Oka A, Suzuki Y, Homma Y, Sato S, Inoue I, Inoko H.
  • Journal Title: Immunogenetics. In press.
  • Peer Reviewed
• [Journal Article] Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset(Callithrix jacchus). (2011)
  • Author(s): Shiina T, Kono A, Westphal N, Suzuki S, Hosomichi K, Kita YF, Roos C, Inoko H, Walter L.
  • Journal Title: Immunogenetics. In press
  • Peer Reviewed
• [Journal Article] Exome Resequencing Combined with Linkage Analysis Identifies Novel PTH1R Variants in Primary Failure of Tooth Eruption in Japanese. (2011)
  • Author(s): Yamaguchi T, Hosomich K, Narita A, Shirota T, Tomoyasu Y, Maki K, Inoue I.
  • Journal Title: J Bone Miner Res. In press
  • Peer Reviewed
• [Journal Article] Primordial Linkage of b2-Microglobulin to the MHC. (2011)
  • Author(s): Ohta Y, Shiina T, Lohr RL, Hosomichi K, Pollin TI, Heist EJ, Suzuki S, Inoko H, Flajnik MF.
  • Journal Title: J Immunol. 186(6) Pages: 3563-3571
  • Peer Reviewed
• [Journal Article] 全エクソンシーケンスによる希少疾患の原因遺伝子同定 (2011)
  • Author(s): 細道一善、井ノ上逸朗
  • Journal Title: 医学のあゆみ 236(6) Pages: 565-570
• [Journal Article] TRIM39 and RNF39 are associated with Behcet's disease independently of HLA-B*51 and.A*26. (2010)
  • Author(s): Kurata R, Nakaoka H, Tajima A, Hosomichi K, Shiina T, Meguro A, Mizuki N, Ohono S, Inoue I, Inoko H.
  • Journal Title: Biochem Biophys Res Commun. 401(4) Pages: 533-537
  • Peer Reviewed
• [Journal Article] Basic characterization of 90 kDa heat shock protein genes HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 expressed in Japanese quail (Coturnix japonica). (2010)
  • Author(s): Nagahori K, Iwamoto S, Maruyama A, Suzuki S, Hosomichi K, Shiina T, Hara H, Yoshida Y, Hanzawa K.
  • Journal Title: Anim Sci J. 81(4) Pages: 513-518
  • Peer Reviewed
• [Journal Article] Positional effects of polymorphisms in probe-target sequences on genoplot images of oligonucleotide microarrays. (2010)
  • Author(s): Cui TL, Nakaoka H, Akiyama K, Kamura H, Hosomichi K, Bae J, Cheong H, Shin H, Yada T, Inoue I.
  • Journal Title: Genet Mol Res. 9(1) Pages: 524-531
  • Peer Reviewed
• [Journal Article] 次世代シークエンサーによるHLA領域のターゲットリシークエンス (2010)
  • Author(s): 細道一善、椎名隆、井ノ上逸朗、猪子英俊
  • Journal Title: 医学のあゆみ 233(13) Pages: 1187-1191
• [Journal Article] BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken. (2009)
  • Author(s): Goto RM, Wang Y, Taylor RL Jr, Wakenell PS, Hosomichi K, Shiina T, Blackmore CS, Briles WE, Miller MM.
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 16740-16745
  • Peer Reviewed
• [Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque. (2009)
  • Author(s): Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T.
  • Journal Title: Immunogenetics. 61(9) Pages: 635-648
  • Peer Reviewed
• [Journal Article] HLA-A allele associations with viral MER9-LTR nucleotide sequences at two distinct loci within the MHC alpha block. (2009)
  • Author(s): Kulski JK, Shigenari A, Shiina T, Hosomichi K, Yawata M, Inoko H.
  • Journal Title: Immunogenetics. 61(4) Pages: 257-270
  • Peer Reviewed
• [Presentation] Application of targeted resequencing methods to the MHC regions on chicken chromosome 16 (GGA16). (2011)
  • Author(s): Hosomichi K, Miller MM, Goto RM, Suzuki S, Inoko H, Inoue I, Shiina T
  • Organizer: Plant & Animal Genome XIX Conference
  • Place of Presentation: Town & Country Convention Center, San Diego, California
  • Year and Date: 20110115-20110119
• [Presentation] Genome sequencing of the major histocompatibility complex regions : comparative genomics from shark to man and re-sequencing of the entire HLA region. (2011)
  • Author(s): Hosomichi K, Shiina T
  • Organizer: Beckman Research Institute Seminar Series
  • Place of Presentation: City of Hope Medical Center, Los Angeles, California
  • Year and Date: 2011-01-18
• [Presentation] Re-sequencing of the entire HLA region for informative polymorphism detection and haplotype map construction (2010)
  • Author(s): Hosomichi K, Shiina T, Wang T, Suzuki S, Inoko H, InoueI
  • Organizer: 60th Annual Meeting of The American Society of Human Genetics (ASHG)
  • Place of Presentation: Washington, DC
  • Year and Date: 20101102-20101106
• [Presentation] 医学・医療への応用を目的としたHLA領域のリシークエンシング (2010)
  • Author(s): 細道一善、椎名隆、王〓、鈴木進悟、田平知子、林健志、猪子英俊、井ノ上逸朗
  • Organizer: 日本人類遺伝学会第55回大会
  • Place of Presentation: 大宮ソニックシティーホール
  • Year and Date: 20101028-20101030
• [Presentation] 疾患ゲノム解明に向けた全エクソンおよびHLA領域ターゲットリシーケンス (2010)
  • Author(s): 細道一善、成田暁、椎名隆、猪子英俊、井ノ上逸朗
  • Organizer: 日本人類遺伝学会第55回大会シンポジウム
  • Place of Presentation: 大宮ソニックシティーホール
  • Year and Date: 20101028-20101030
• [Presentation] 次世代シークエンサーによるHLAハプロタイプのリシークエンス (2010)
  • Author(s): 細道一善、椎名隆、井ノ上逸朗、猪子英俊
  • Organizer: 第19回日本組織適合性学会大会シンポジウム
  • Place of Presentation: 東京大学本郷キャンパス
  • Year and Date: 20100917-20100919
• [Presentation] Re-sequencing of the human MHC region toward to biomedical application for various animal genomes (2010)
  • Author(s): Hosomichi K, Shiina T, Wang T, Suzuki S, Inoko H, InoueI
  • Organizer: 9th IVIS International Veterinary Immunology Symposium
  • Place of Presentation: Tower Holl Funabori, Edogawa-ku, Tokyo
  • Year and Date: 20100816-20100820
• [Presentation] Resequencing of the entire major histocompatibility complex regions to identify haplotype structure (2010)
  • Author(s): Hosomichi K, Shiina T, Wang T, Suzuki S, Inoko H, InoueI
  • Organizer: 日本進化学会2010年大会国際ワークショップ
  • Place of Presentation: 東京工業大学 大岡山キャンパス
  • Year and Date: 20100802-20100805
• [Presentation] Development of personal genome analysis method on the entire HLA region (2009)
  • Author(s): Hosomichi K, Shiina T, Wang T, Kawata H, Inoko H, Inoue I
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] HLA領域のパーソナルゲノム解析法の開発と疾患関連解析への応用 (2009)
  • Author(s): 細道一善
  • Organizer: 第4回バイオインフォマティクス研究者と医学研究者の交流会
  • Place of Presentation: 東京大学柏キャンパス
  • Year and Date: 2009-11-20
• [Presentation] HLA領域のパーソナルゲノム解析法の開発 (2009)
  • Author(s): 細道一善、猪子英俊、河田寿子、井ノ上逸朗、椎名隆
  • Organizer: 第18回日本組織適合性学会大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-26
• [Presentation] HLA領域のパーソナルゲノム解析法の開発 (2009)
  • Author(s): 細道一善、椎名隆、王、河田寿子、猪子英俊、井ノ上逸朗
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: グランドプリンスホテル高輪
  • Year and Date: 2009-09-25
• [Remarks] ホームページ等
  • URL: http://www.nig.ac.jp/section/inoue/inoue-j.html