2010 Fiscal Year Final Research Report
A biochemical study of cancer cell growth inhibitors from marine cyanobacteria
| Project/Area Number |
21710237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
TERUYA Toshiaki University of the Ryukyus, 教育学部, 准教授 (90375428)
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| Project Period (FY) |
2009 – 2010
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| Keywords | シアノバクテリア / ビセリングビアサイド / ビセブロモアミド / プロテインキナーゼ阻害 |
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| Research Abstract |
In our ongoing efforts to isolate novel marine cyanobacterial metabolites with antitumor activity, we found bisebromoamide and biselyngbyaside. Bisebromoamide exhibited potent protein kinase inhibition: the phosphorylation of ERK (extracellular signal regulated protein kinase) in NRK cells by PDGF (platelet-derived growth factor)-stimulation was selectively inhibited by treatment with 10 to 0.1μM of bisebromoamide. Bisebromoamide had no effect on the phosphorylation of AKT, PKD, PLCγ1, or S6 ribosomal protein at 10-0.1μM. Biselyngbyaside exhibited cytotoxicity against HeLa S_3 cells with an IC_<50> value of 0.1μg/mL and exhibited differential cytotoxicities : the central nervous system cancer SNB-78 (GI_<50> 0.036μM) and lung cancer NCI H522 (GI_<50> 0.067μM) were especially sensitive. Biselyngbyaside was COMPARE-negative, indicating that it likely inhibits cancer cell proliferation through a novel mechanism.
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[Journal Article] Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice2010
Author(s)
Lee, Y.Sil.; Cha, B.Y.; Saito, K.; Yamakawa, H.; Choi, S.S.; Yamaguchi, K.; Yonezawa, T.; Teruya, T.; Nagai, K.; Woo, J.T.
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Journal Title
Biochemical Pharmacology 79
Pages: 1674-1683
Peer Reviewed
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