2010 Fiscal Year Final Research Report
Functional analysis of Shu complex, a new mediator of Rad51 protein in recombination
| Project/Area Number |
21770005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
SASANUMA Hiroyuki Osaka University, 蛋白質研究所, 特任研究員 (00531691)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子遺伝 / Rad51 / Dmc1 / 減数分裂 |
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| Research Abstract |
Homologous recombination is essential mechanism to repair DNA damage, such as double strand breaks. In this grant period, I found that Shu complex assists the role of Rad51 protein, which plays a central role in homologous recombination. Based on research proposal, I also successfully determined the crystal structure of Shu complex, thereby could clarified the structural relationship between Rad51 and Shu protein complex.
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Research Products
(14 results)
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[Journal Article] Rec8 Guides Canonical Spoll Distribution along Yeast Meiotic Chromosomes.2009
Author(s)
Kugou, K., Fukuda, T., Yamada, S., Ito, M., Sasanuma, H., Mori, S., Katou, Y., Itoh, T., Matsumoto, K., Shibata, T., et al.
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Journal Title
Mol Biol Cell 345
Pages: 1939-4586
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[Journal Article] Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.2008
Author(s)
Sasanuma, H., Hirota, K., Fukuda, T., Kakusho, N., Kugou, K., Kawasaki, Y., Shibata, T., Masai, H., Ohta, K.
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Journal Title
Genes Dev 22
Pages: 398-410
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