2010 Fiscal Year Final Research Report
Involvement of the Cdc7 protein kinse in sister chromatid cohesion
| Project/Area Number |
21770186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
TAKAHASHI Tatsuro Osaka University, 大学院・理学研究科, 助教 (50452420)
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| Research Collaborator |
ITAOKA Takako 大阪大学, 大学院・理学研究科, 修士課程2年
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| Project Period (FY) |
2009 – 2010
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| Keywords | 染色体分配 / 姉妹染色体接着 / コヒーシン / Cdc7-kinase / Scc2-Scc4 / 染色体 / アフリカツメガエル |
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| Research Abstract |
Faithful duplication and segregation of chromosomes are essential for cell proliferation. Replicated sister chromosomes are physically linked during their synthesis (sister chromatid cohesion), ensuring identification of chromosome pairs to be distributed into daughter cells. Although the cohesion establishment reaction cooperates with DNA replication, the mechanism how cohesion and replication couple remains unclear. In this study, we have examined how a DNA replication protein interacts with a cohesion protein using Xenopus egg extracts.
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