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2010 Fiscal Year Final Research Report

Involvement of the Cdc7 protein kinse in sister chromatid cohesion

Research Project

  • PDF
Project/Area Number 21770186
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI Tatsuro  Osaka University, 大学院・理学研究科, 助教 (50452420)

Research Collaborator ITAOKA Takako  大阪大学, 大学院・理学研究科, 修士課程2年
Project Period (FY) 2009 – 2010
Keywords染色体分配 / 姉妹染色体接着 / コヒーシン / Cdc7-kinase / Scc2-Scc4 / 染色体 / アフリカツメガエル
Research Abstract

Faithful duplication and segregation of chromosomes are essential for cell proliferation. Replicated sister chromosomes are physically linked during their synthesis (sister chromatid cohesion), ensuring identification of chromosome pairs to be distributed into daughter cells. Although the cohesion establishment reaction cooperates with DNA replication, the mechanism how cohesion and replication couple remains unclear. In this study, we have examined how a DNA replication protein interacts with a cohesion protein using Xenopus egg extracts.

  • Research Products

    (2 results)

All 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (1 results)

  • [Journal Article] Sister acts : coordinating DNA replication and cohesion establishment.2010

    • Author(s)
      Sherwood, R.*^Takahashi, T.S., *^Jallepalli, P.V.
    • Journal Title

      Genes Dev.(*^corresponding authors) 24

      Pages: 2723-2731

    • Peer Reviewed
  • [Remarks] ホームページ等

    • URL

      http://www.bio.sci.osaka-u.ac.jp/bio_web/lab_page/masukata/research/index.html

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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