2010 Fiscal Year Final Research Report
Single molecular analysis of sumoylation-dependent chromatin remodeling factor
| Project/Area Number |
21770197
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
OGAWA Hidesato National Institute of Information and Communications Technology, 4, 専攻研究員 (20370132)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 転写因子 / 核内受容体 / クロマチン / SUMO化修飾 / 転写制御 / 核内構造 |
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| Research Abstract |
The small ubiquitin-like modifier (SUMO) conjugates transcription factors, and suppresses the transcription of their target genes. Although various SUMO-conjugated transcription factors have been isolated, mechanisms how sumoylated-transcription factors suppress transcription remain largely unknown. To understand mechanisms of SUMO-dependent transcriptional repression, we purified interacting partners for a nuclear receptor and identified ARIP4 known as a SNF2 chromatin-remodeling factor.
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[Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads.2010
Author(s)
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K.
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Journal Title
Endocrinology 151(12)
Pages: 5893-5904
Peer Reviewed
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