2010 Fiscal Year Final Research Report
A novel function of Jagged in the zebrafish lateral line development
Project/Area Number |
21770201
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Cell biology
|
Research Institution | University of Tsukuba |
Principal Investigator |
MIZUNO Tomoaki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (80529032)
|
Project Period (FY) |
2009 – 2010
|
Keywords | ゼブラフィッシュ / Notch |
Research Abstract |
We studied an anti-apoptotic role of Jagged1 using the zebrafish lateral line development as a model system. Jagged1 knockdown-induced apoptosis was suppressed by knockdown of p53 tumor suppressor. Expression of Six1 transcription factor was decreased in Jagged1 knockdown embryos. Similar to Jagged1, Six1 knockdown induced apoptosis. These results imply that p53 and Six1 are involved in regulation of anti-apoptosis via Jagged1.
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Research Products
(7 results)