2010 Fiscal Year Final Research Report
The roles and specificities of the regulators for small GTP-binding proteins in the regulation of neuronal cell location
| Project/Area Number |
21770202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
KATOH Hironori Kyoto University, 大学院・生命科学研究科, 准教授 (50303847)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / 細胞・組織 / シグナル伝達 / 発生・分化 |
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| Research Abstract |
Cerebral cortex is developed particularly in mammals, and recent studies using slice culture, in vivo gene expression, knockout mice, and imaging system have elucidated the structure of neuronal circuit and developmental process in the cerebral cortex. Rho family small GTPases act as molecular switches in cells and regulate cytoskeleton to control cell migration and neurite outgrowth in cultured cells. However, their roles in the development of cerebral cortex have not yet well understood. In this study, we studied the role of RhoG in the developing mouse cerebral cortex and found that RhoG promoted neuronal progenitor cell proliferation.
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[Journal Article] Ephexin4 and EphA2 mediate cell migration through a RhoG-depemdemt mechanism.2010
Author(s)
Hiramoto-Yamaki, N., Takeuchi, S., Ueda, S., Harada, K., Fujimoto, S., Negishi, M., Katoh, H.
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Journal Title
J.Cell Biol. 190
Pages: 461-477
Peer Reviewed
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