2010 Fiscal Year Final Research Report
Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
| Project/Area Number |
21770208
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIBUYA Toshiharu Osaka University -> 大阪大学, 医学系研究科, 助教 (70448033)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 酸化ストレス / ミトコンドリア / 細胞内情報伝達 |
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| Research Abstract |
An experimental assay system was employed to generate excessive ROS in the mitochondria in a precisely controlled spatio-temporal manner. Using mammalian cells and worm C. elegans generating mitochondrial ROS, I analyzed the stress response and the molecular mechanism induced by mitochondrial ROS in vitro and in vivo. I revealed that factors involved in the mitochondrial permeability transition (Cyclophilin D and Ca++) were contributed to the mitochondrial oxidative stress response.
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Research Products
(4 results)
