2010 Fiscal Year Final Research Report
Role of PFR cells during digit identity determination.
| Project/Area Number |
21770226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takayuki Tohoku University, 加齢医学研究所, 助教 (40451629)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 指の個性 / 骨 / BMP / PFR / 指間部 / ニワトリ |
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| Research Abstract |
We found that the cells located distal to the digital lay received positional information from interdigit. These cells get BMP signaling from adjacent interdigit located at the posterior side. I named this region 'PFR'. We found that digit identity is controlled by physical flow in the interdigit, and this conclusion brings us new insight how morphogen gradient works in the embryos. Further, we identified single point mutation in Silkie chicken that causes preaxial polydactyly in the leg. We will publish this data in this May, in press now
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Research Products
(5 results)
