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2010 Fiscal Year Final Research Report

Regulation of the onset of neuronal migration in the developing mouse neocortex

Research Project

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Project/Area Number 21770230
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

ITOH Yasuhiro  The University of Tokyo, 分子細胞生物学研究所, 助教 (50508108)

Project Period (FY) 2009 – 2010
Keywords細胞分化
Research Abstract

During the neocortical development, neural precursor cells are located in the ventricular zone by attaching their apical process to the ventricular surface through cadherin-based adherens junctions and form a pseudostratified epithelial structure. Once these cells commit to become neurons or intermediate neuronal progenitors, they delaminate and start migration toward the pial surface. However, it has remained unclear how the detachment from the neuroepithelium, the first step of radial migration, is coordinated with neuronal fate commitment. This study revealed a mechanism that links these two processes.

Research Products

(3 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.2009

    • Author(s)
      大石康二, 綿谷健治, 伊藤靖浩, 岡野栄之, Francois Guillemot, 仲嶋一範, 後藤由季子
    • Journal Title

      PNAS 106

      Pages: 13064-13069

    • Peer Reviewed
  • [Presentation] 発生期マウス大脳皮質におけるリン酸化ペプチドの解析2010

    • Author(s)
      伊藤靖浩、後藤由季子
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会ランチョンセミナー
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-12-08
  • [Presentation] Regulation of the onset of neuronal migration during mouse neocortical development2009

    • Author(s)
      伊藤靖浩、後藤由季子
    • Organizer
      第32回日本分子生物学会年会ワークショップ・ポスターセッション
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-12

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Published: 2012-02-12   Modified: 2016-04-21  

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