2010 Fiscal Year Final Research Report

Regulation of the onset of neuronal migration in the developing mouse neocortex

Research Project

Project/Area Number	21770230
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Developmental biology
Research Institution	The University of Tokyo
Principal Investigator	ITOH Yasuhiro The University of Tokyo, 分子細胞生物学研究所, 助教 (50508108)
Project Period (FY)	2009 – 2010
Keywords	細胞分化
Research Abstract	During the neocortical development, neural precursor cells are located in the ventricular zone by attaching their apical process to the ventricular surface through cadherin-based adherens junctions and form a pseudostratified epithelial structure. Once these cells commit to become neurons or intermediate neuronal progenitors, they delaminate and start migration toward the pial surface. However, it has remained unclear how the detachment from the neuroepithelium, the first step of radial migration, is coordinated with neuronal fate commitment. This study revealed a mechanism that links these two processes.

(3 results)