2010 Fiscal Year Final Research Report
Dissecting cell competition focused on the output switching of JNK signaling
| Project/Area Number |
21770233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kobe University |
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Principal Investigator |
OHSASWA Shizue Kobe University, 大学院・医学研究科, グローバルCOE研究員 (80515065)
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| Research Collaborator |
IGAKI Tatsushi 神戸大学, 大学院・医学研究科, 特命准教授 (00467648)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞競合 / 細胞間コミュニケーション / がん抑制 |
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| Research Abstract |
A newly emerged oncogenic cell in the epithelium has to confront anti-tumor selective pressures in the host tissue. However, the underlying mechanism is poorly understood. Using Drosophila model system, we found that normal epithelial cells activate JNK signaling through "cell competition" in response to the emergence of oncogenic polarity-deficient cells, which activates phagocytic pathway, thereby eliminating oncogenic neighbors by engulfment.
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