2011 Fiscal Year Final Research Report
Role of the Ca2+ signaling pathway in the regulation of the life span in yeast
| Project/Area Number |
21780095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
MIZUNUMA Masaki 広島大学, 大学院・先端物質科学研究科, 准教授 (10343295)
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| Project Period (FY) |
2009 – 2011
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| Keywords | カルシウム / 老化 / 寿命 / 酵母 |
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| Research Abstract |
We are focus on the roles of the Ca^<2+>/ calmodulin-dependent protein phosphatase calcineurin in budding yeast. Especially, here, we investigated a relationship between Ca^<2+>-signaling and lifespan. We found that Ca^<2+> affected the replicative lifespan(RLS) of yeast. The increase in calcineurin activity by either the zds1 deletion or the constitutively activated calcineurin reduced RLS. Further, the calcineurin deletion per se promoted ageing without impairing the gene silencing typically observed in short-lived sir mutants, indicating that calcineurin plays an important role in a regulation of RLS even under normal growth condition. Thus, our results indicate that Ca^<2+> homeostasis/ Ca^<2+>-signaling is required to regulate longevity in budding yeast.
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