2010 Fiscal Year Final Research Report
Studies for the efficient synthesis of bioactive terpenoids
| Project/Area Number |
21780108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI Naoki The University of Tokyo, 大学院・農学生命科学研究科, 助教 (60463882)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アザジラクチン / 昆虫摂食阻害 / カモブツシンA / ジテルペン / アルカロイド |
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| Research Abstract |
I have studied for the efficient synthesis of bioactive terpenoids (azadirachtin and chamobtusin A). Construction of the full carbon skeleton of azadirachtin has been accomplished by using tandem radical cyclization in very short steps. Total synthesis of chamobtusin A has also been accomplished by using intramolecular aza-Michael cyclization as a key reaction.
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