2010 Fiscal Year Final Research Report
Role of CaSR as dietary peptide sensor and search for dietary protein receptor in the gut
| Project/Area Number |
21780118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
HIRA Tohru Hokkaido University, 大学院・農学研究院, 助教 (10396301)
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| Project Period (FY) |
2009 – 2010
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| Keywords | カルシウム感知受容体 / 消化管ホルモン / コレシストキニン / 食品ペプチド / 食品たんぱく質 |
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| Research Abstract |
In this research project, we have investigated the function of calcium-sensing receptor (CaSR) as the receptor for luminal dietary peptides in gastrointestinal endocrine cells. Secretions of a gut hormone CCK induced by various dietary peptides were partially inhibited by the presence of CaSR antagonists. CaSR-expressing kidney cells also responded to various dietary peptides. These results suggest that CaSR is one of the receptor for dietary peptides in the gastrointestinal tract.
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