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2010 Fiscal Year Final Research Report

Studies on inhibitory effect against mast cell function and anti-allergic property of GABA

Research Project

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Project/Area Number 21780122
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionNiigata University

Principal Investigator

HARA Takashi  Niigata University, 自然科学系, 准教授 (20323959)

Project Period (FY) 2009 – 2010
KeywordsGABA / GABA_B受容体 / マスト細胞 / 脱顆粒 / アレルギー
Research Abstract

We found that gamma-amino-butyric acid type B (GABA_B) receptor is expressed in mast cells, while gamma-amino-butyric acid (GABA) and baclofen, a GABA_B receptor agonist, exhibit suppressive effect on histamine release in mast cells. Expression of GABA_B receptor was also detected in T cells and NK cells. Oral administration of GABA or baclofen successfully suppressed serum IgE level in Th2-dominant BALB/c mice. The mechanisms underlying this suppression by GABA included the alteration of Th1/Th2 balance toward to Th1-biased state. There is the possibility that GABA can down-regulate mast cell functions and IgE production via GABA_B receptor, leading to attenuation of IgE-mediated allergic responses.

  • Research Products

    (2 results)

All 2010

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] Influence of γ-aminobutyric Acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice.2010

    • Author(s)
      Hori A., Hara T., Sato K., Joh T.
    • Journal Title

      Bulletin of the Faculty of Agriculture Niigata University Vol.62(2)

      Pages: 117-123

  • [Presentation] 血中高IgEレベルマウス脾細胞のIFN-γおよびIL-4産生に及ぼすγ-アミノ酪酸(GABA)の影響2010

    • Author(s)
      石川公亮, 寺平拓也, 和田紘稔, 原崇, 城斗志夫
    • Organizer
      日本食品科学工学会第57回大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2010-09-02

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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