• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Mechanism of the enhancement of hepatic insulin action induced by protein malnutrition

Research Project

  • PDF
Project/Area Number 21780134
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionNippon Medical School

Principal Investigator

SUZUKI Yuka (SUZUKI TOYOSHIMA Yuka)  日本医科大学, 老人病研究所, 助教 (70516070)

Project Period (FY) 2009 – 2011
Keywordsインスリン / 肝臓 / タンパク質栄養
Research Abstract

Protein malnutrition induces lipid accumulation in the liver, which was liked with the enhancement of insulin signaling in the liver. Furthermore, in contrast to the liver, in white adipose tissue(WAT), protein malnutrition suppresses insulin action. Taken together with our results, when energy utilization is reduced under protein malnutrition, energy that is not utilized is preferentially incorporated into the liver and synthesized to lipids. The enhancement of insulin signaling in the liver and the suppression of insulin signaling in WAT may play important roles in the preferential distribution of lipids in the liver during protein malnutrition.

Research Products

(6 results)

All 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver2010

    • Author(s)
      Yuka Toyoshima, Reiko Tokita, Yoichiro Ohne, Fumihiko Hakuno, Tadashi Noguchi, Shiro Minami, Hisanori Kato, Shin-Ichiro Takahashi
    • Journal Title

      Journal of Molecular Endocrinology

      Volume: 45 Pages: 329-340

    • DOI

      DOI:10.1677/JME-10-0102

    • Peer Reviewed
  • [Presentation] 低タンパク質栄養状態に応答して起こる脂肪蓄積の臓器特異的調節2011

    • Author(s)
      豊島由香
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2011-05-23
  • [Presentation] 低タンパク質食を給餌したラット肝臓に中性脂肪蓄積を引き起こす内分泌系およびインスリンシグナルの変動2011

    • Author(s)
      豊島由香
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
  • [Presentation] Suppression of insulin signaling in white adipose tissues contributes to preferential lipid accumulation in rat liver under protein malnutrition2010

    • Author(s)
      Yuka Toyoshima
    • Organizer
      5th International Congress of the GRS-IGF Society
    • Place of Presentation
      New York、USA
    • Year and Date
      2010-10-06
  • [Presentation] Effects of protein restriction on insulin signals in liver, muscle, and adipose tissues of rats in response to endogenous insulin2009

    • Author(s)
      Yuka Toyoshima
    • Organizer
      19^(th) International Congress of Nutrition
    • Place of Presentation
      タイ・バンコク
    • Year and Date
      20091004-09
  • [Presentation] 低タンパク質食給餌に応答した肝臓のインスリンシグナルの増強と脂肪蓄積2009

    • Author(s)
      豊島由香
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi