2010 Fiscal Year Final Research Report
Studies on the protective effects of polyunsaturated fatty acids in Alzheimer's disease.
Project/Area Number |
21780139
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Food science
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Research Institution | Nihon University (2010) National Institute for Longevity Sciences,NCGG (2009) |
Principal Investigator |
HOSONO Takashi Nihon University, 生物資源科学部, 助手 (80445741)
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Project Period (FY) |
2009 – 2010
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Keywords | 食品機能 / アルツハイマー病 / 多価不飽和脂肪酸 / アラキドン酸 / ドコサヘキサエン酸 |
Research Abstract |
In this study, we examined the effects of dietary supplementation with polyunsaturated fatty acid (arachidonic acid or docosahexaenoic acid) on Alzheimer's disease pathology. Polyunsaturated fatty acid diet prevents memory impairment in Alzheimer model Tg2576 mice. APP processing to generate soluble APP and Aβ synthesis were enhanced, but the Aβ1-42/Aβ1-40 ratio was decreased in Tg2576 mice fed with the arachidonic acid or docosahexaenoic acid diet. These findings suggest that polyunsaturated fatty acid diet could prevent cognitive dysfunction, and alter APP processing and Aβ1-42/Aβ1-40 ratio in Tg2576 mice.
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[Journal Article] Replacing white rice with pre-germinated brown rice mildly ameliorates hyperglycemia and imbalance of adipocytokine levels in type 2 diabetes model rats.2010
Author(s)
Torimitsu M, Nagase R, Yanagi M, Homma M, Sasai Y, Ito Y, Hayamizu K, Nonaka S, Hosono T, Kise M, Seki T, Ariga T.
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Journal Title
Journal of nutritional science and vitaminology 56
Pages: 287-292
Peer Reviewed
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[Journal Article] Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function.2010
Author(s)
Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M.
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Journal Title
Journal of biological chemistry 285(49)
Pages: 38382-38388
Peer Reviewed
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