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2010 Fiscal Year Final Research Report

The origin and purpose of fast skeletal muscle myosin heavy chain gene cluster of vertebrates

Research Project

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Project/Area Number 21780198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionKitasato University

Principal Investigator

IKEDA Daisuke  Kitasato University, 海洋生命科学部, 講師 (00466806)

Project Period (FY) 2009 – 2010
Keywordsミオシン重鎖 / クラスター / ゲノム / 筋発生 / ヤツメウナギ
Research Abstract

Myosin heavh chain (MYH) is essential protein for a wide range of motile processes in eukaryotic cells and fast skeletal MYH genes (MYHs) formed clusters in mammals and teleosts. In the present study, we found that the fast skeletal MYHs formed a cluster also in the lamprey, agnathan vertebrate. Moreover, in vivo promoter assay demonstrated that lamprey fast skeletal MYH promoters could drive reporter gene to express in the fast skeletal muscle in zebrafish embryo. These results suggest that in the early vertebrates, fast skeletal MYHs had already formed clusters and the basic mechanism for transcriptional control of skeletal muscle development had been determined.

  • Research Products

    (5 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] A 5'-flanking region of embryonic-type myosin heavy chain gene, MYH_<M743-2>, from torafugu Takifugu rubripes regulates developmental muscle-specific expressions.2011

    • Author(s)
      Lubna Yasmin, Shigeharu Kinoshita, Dadasaheb B.Akolkar, Daisuke Ikeda, Yosuke Ono, Shugo Watabe
    • Journal Title

      Comp. Biochem. Physiol., Part D 6

      Pages: 76-81

    • Peer Reviewed
  • [Journal Article] Early development of medaka Oryzias latipes muscles as revealed by transgenic approaches using embryonic and larval types of myosin heavy chain genes.2010

    • Author(s)
      Yosuke Ono, Shigeharu Kinoshita, Daisuke Ikeda, Shugo Watabe
    • Journal Title

      Dev. Dyn. 239

      Pages: 1807-1817

    • Peer Reviewed
  • [Journal Article] Three embryonic myosin heavy chain genes encoding different motor domain structures from common carp show distinct expression patterns in cranial muscles.2010

    • Author(s)
      Daisuke Ikeda, Yoshiaki Nihei, Yosuke Ono, Shugo Watabe
    • Journal Title

      Mar. Genomics 3

      Pages: 1-9

    • Peer Reviewed
  • [Presentation] カワヤツメ速筋型ミオシン重鎖遺伝子クラスターの解析2011

    • Author(s)
      池田大介
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都)
    • Year and Date
      2011-03-28
  • [Presentation] ヤツメウナギ類速筋型ミオシン重鎖遺伝子クラスターに含まれるプロモータ領域の解析2010

    • Author(s)
      池田大介
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県)
    • Year and Date
      2010-03-29

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Published: 2012-02-13   Modified: 2016-04-21  

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