2010 Fiscal Year Final Research Report
The role of vector saliva in transmission of vector-borne diseases
| Project/Area Number |
21780276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KATO Hirotomo Yamaguchi University, 農学部, 准教授 (00346579)
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| Project Period (FY) |
2009 – 2010
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| Keywords | サシチョウバエ / 唾液 / リーシュマニア / 生理活性物質 / 免疫 |
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| Research Abstract |
In order to disclose the mechanism of enhancement of Leishmania infection by sand fly saliva, DNA vaccines encoding dominant salivary proteins from Phlebotomus duboscqi were prepared and immune responses induced by these antigens were assessed. As the result, three salivary proteins were found to effectively induce humoral responses in mice. Since humoral immune responses were shown to exacerbate Leishmania infection, these salivary proteins were suggested to associate with the enhancement of the infection via host immunity.
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Research Products
(20 results)
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[Journal Article] Use of FTA cards for direct sampling of patients' lesions in the ecological study of cutaneous leishmaniasis.2010
Author(s)
Kato H, Caceres AG, Mimori T, Ishimaru Y, Sayed ASM, Fujita M, Iwata H, Uezato H, Velez LN, Gomez EAL, Hashiguchi Y.
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Journal Title
J Clin Microbiol 48
Pages: 3661-3665
Peer Reviewed
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[Journal Article] Detection of multiple sapovirus genotypes and genogroups in oyster-associated outbreaks.2009
Author(s)
Nakagawa-Okamoto R, Arita-Nishida T, Toda S, Kato H, Iwata H, Akiyama M, Nishio O, Kimura H, Noda M, Takeda N, Oka T.
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Journal Title
Jpn J Infect Dis. 62
Pages: 63-66
Peer Reviewed
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