2010 Fiscal Year Final Research Report
The effect of physiological antidepressant treatments on the gene expression pattern in hypothalamic nuclei
| Project/Area Number |
21790074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
SEGI Eri Kyoto University, 薬学研究科, 准教授 (70378628)
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| Research Collaborator |
SUGIMOTO Yukihiko 熊本大学, 薬学研究科, 教授
OKUNO Yasushi 京都大学, 薬学研究科, 教授
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| Project Period (FY) |
2009 – 2010
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| Keywords | 精神分子薬理学 / 抗うつ治療 / 遺伝子発現 / 視床下部 |
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| Research Abstract |
The exact mechanisms underlying the actions of physiological antidepressant treatment (electroconvulsive therapy) are not yet understood. To identify the gene expression changes by antidepressant treatments in the paraventricular nucleus of hypothalamus (PVN), microarray analysis was performed. I identified several genes as differentially regulated in PVN by electroconvulsive therapy. Although the involvement of the identified gene products in antidepressant effects still remains unknown, some of down-regulated genes, such as protein kinase C and neuropeptide Y, have been reported their relevance to psychological disorders.
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[Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.2009
Author(s)
Yamaoka K, Yano A, Kuroiwa K, Morimoto K, Inazumi T, Hatae N, Tabata H, Segi-Nishida E, Tanaka S, Ichikawa A, Sugimoto Y.
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Journal Title
Biochem Biophys Res Commun. 389(4)
Pages: 678-682
Peer Reviewed
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