2010 Fiscal Year Final Research Report
Mechanism underlying induction of human CYP1A1 gene by major phytocannabinoids
| Project/Area Number |
21790135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
YAMAORI Satoshi Hokuriku University, 薬学部, 助教 (40360218)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 中毒学 / 異物代謝 / 分子毒性学 |
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| Research Abstract |
Effects of marijuana component(s), especially phytocannabinoids, on expression of cytochrome P450 1A1 (CYP1A1) in human hepatic cells were examined to clarify whether or not marijuana component(s) induces the expression of CYP1A1. Cannabidiol, one of the major phytocannabinoids in marijuana, increased the expression level of hepatic CYP1A1. The induction of CYP1A1 by cannabidiol may be mediated through common and/or uncommon pathway(s).
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