2010 Fiscal Year Final Research Report
Molecular analysis of the alteration in renal excretion of drugs by liver ischemia-reperfusion injury
| Project/Area Number |
21790166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
IKEMURA Kenji Kinjo Gakuin University, 薬学部, 助教 (70513935)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肝虚血再灌流障害 / 酸化ストレス / 薬物トランスポータ |
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| Research Abstract |
The effect of liver I/R injury on the renal excretion of drugs was investigated to establish the individual drug therapy after liver transplantation. This study suggested that the systemic clearance of cimetidine was decreased after liver I/R, and that this alternation is attributable to the decreased renal excretion mediated by rOCT2 and rMATE1 in the kidney. The present findings provide useful information for our understanding of renal disposition of cationic drugs in liver I/R injury.
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