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2010 Fiscal Year Final Research Report

Analysis on molecular mechanisms of cell differentiation from neural stem cells to specific neurons and glia

Research Project

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Project/Area Number 21790183
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKumamoto University

Principal Investigator

TAKEBAYASHI Hirohide  Kumamoto University, 大学院・生命科学研究部, 准教授 (60353439)

Project Period (FY) 2009 – 2010
Keywords細胞分化 / 組織形成
Research Abstract

Olig2 is basic helix-loop-helix transcription factor essential for motoneuron and oligodendrocyte development. In order to investigate Olig transcription complex, which regulates differentiation from neural stem cell to specific subtype of neuron and glial cells, we screened Olig2-binding factors. We identified two factors, which are named Olig Binding Protein1 (OBP1), Olig Binding Protein2 (OBP2). Furthermore, we identified Olig2 as a phospho-protein and its phosphorylation sites. We revealed transcriptional regulation of Olig2 transcription factor.

  • Research Products

    (8 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the adult mouse brain.2011

    • Author(s)
      Kim WR, Chun SK, Kim TW, Kim H, Ono K, Takebayashi H, Ikenaka K, Oppenheim RW, Sun W.
    • Journal Title

      Eur J Neurosci 33

      Pages: 599-611

    • Peer Reviewed
  • [Journal Article] Genetically-defined lineage tracing of Nkx2.2-expressing cells in chick spinal cord.2011

    • Author(s)
      Goto H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K.
    • Journal Title

      Dev Biol 349

      Pages: 504-511

    • Peer Reviewed
  • [Journal Article] Origin of new glial cells in the intact and injured adult spinal cord.2010

    • Author(s)
      Barnabe-Heider F, Goritz C, Sabelstrom H, Takebayashi H, Pfrieger FW, Meletis K, Frisen J.
    • Journal Title

      Cell Stem Cells 7

      Pages: 470-482

    • Peer Reviewed
  • [Journal Article] Olig2transcription factor in the developing and injured forebrain : cell lineage and glial development.2009

    • Author(s)
      Ono K, Takebayashi H, Ikenaka K.
    • Journal Title

      Mol.Cells 27

      Pages: 397-401

  • [Presentation] Novel phenotype of Olig2 knockout mice : possible involvement of motoneuron-derived factor in sensory neuron development.2010

    • Author(s)
      Takebayashi H, Usui N, Watanabe K, Ono K, Tamamaki N, Ikenaka K.
    • Organizer
      The 29th NAITO Conference on Glia World -Dynamic Function of Glial Cells in the Brain.
    • Place of Presentation
      Shonan Village, Hayama, Kanagawa
    • Year and Date
      20101005-20101008
  • [Presentation] 感覚神経発生おける運動ニューロン由来因子の役割2010

    • Author(s)
      竹林浩秀
    • Organizer
      第115回解剖学会岩手県民会館
    • Place of Presentation
      岩手
    • Year and Date
      20100328-20100330
  • [Presentation] Analysis on brain left-right asymmetry.2010

    • Author(s)
      Takebayashi H, Bepari AK, Usui N, Ikenaka K, Tamamaki N.
    • Organizer
      Fourth Neural Development Seminar
    • Place of Presentation
      Okazaki Conference Center, Okazaki, Aichi
    • Year and Date
      20100319-20100320
  • [Presentation] Roles of motoneuron-derived NT-3 on sensory neuron development.2009

    • Author(s)
      Takebayashi H.
    • Organizer
      9th Biennial Satellite Meeting of the ISN on Myelin Biology
    • Place of Presentation
      TEMF Hotel, Gyeongju, South Korea
    • Year and Date
      20090819-20090823

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Published: 2012-02-13   Modified: 2016-04-21  

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