2011 Fiscal Year Final Research Report
Role of SCGB3A2 in pulmonary fibrosis
| Project/Area Number |
21790207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Yamagata University (2010-2011)
Yokohama City University (2009) |
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Principal Investigator |
KUROTANI Reiko 山形大学, 大学院・理工学研究科, 助教 (00453043)
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| Project Period (FY) |
2009 – 2011
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| Keywords | SCGB3A2 / 肺線維症 |
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| Research Abstract |
An explosive number of people are affected by fibrosis worldwide in these days, and the morbidity and mortality rates are increasing every year. The exploration and/or development of a definitive medicine are urgently required. We report that SCGB3A2 drastically reduces the severity of lung fibrosis using bleomycin (BLM)-induced mouse model. Mice were intravenously administered SCGB3A2 for 7 days starting at day 14 after administration of BLM by intratracheal intubation. Fibrosis foci were remarkably reduced by SCGB3A2 in lung lobes and the number of neutrophils and macrophages was also reduced in branchoalveolar lavage fluid (BALF). Additionally, when lung fibroblast cells isolated from adult mice were differentiated into myofibroblast cells by TGFβ, the differentiation was inhibited by SCGB3A2 as judged by morphology and reduced expression of a smooth muscle actin (αSMA). Collagen 1a2 and 3a1 gene expression was also decreased in the presence of SCGB3A2.
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Research Products
(30 results)
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[Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation2011
Author(s)
Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S
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Journal Title
J Biol Chem
Volume: 286(22)
Pages: 19682-19692
Peer Reviewed
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[Journal Article] Differential Regulation of Vascular Tone and Remodeling via Stimulation of Type 2 and Type 6 Adenylyl Cyclases in the Ductus Arteriosus2010
Author(s)
Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
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Journal Title
Circ Res
Volume: 106(12)
Pages: 1882-1892
Peer Reviewed
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[Journal Article] Caveolin gene transfer improves glucose metabolism in diabetic mice2010
Author(s)
Otsu K, Toya Y, Oshikawa J, Kurotani R, Yazawa T, Sato M, Yokoyama U, Umemura S, Minamisawa S, Okumura S, Ishikawa Y
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Journal Title
Am J Physiol Cell Physiol
Volume: 298(3)
Pages: C450-456
Peer Reviewed
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[Journal Article] HING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression2009
Author(s)
Kumamoto K, Fujita K, UKurotani RU, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC
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Journal Title
Int J Cancer
Volume: 125(6)
Pages: 1306-1315
Peer Reviewed
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