Non-ionotropic functions of "ionotropic" glutamate receptor channels.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790213
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: KAKEGAWA Wataru Keio University, 医学部, 助教 (70383718)
• Project Period (FY): 2009 – 2010
• Keywords: イオンチャネル / シナプス可塑性 / 記憶・学習 / 小脳

Research Abstract

To understand the non-ionotropic functions of ionotropic glutamate receptors (iGluRs), we analyzed the functions of the δ2 receptor which is a member of iGluRs. Interestingly, the external N-terminus and the internal C-terminus of the δ2 receptor regulated synapse formation and synaptic plasticity, respectively, in a channel property-independent manner. These results indicate that the δ2 receptors can be a good model to elucidate the whole pictures of iGluRs.

Research Products

• [Journal Article] D-Serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor. (2011)
  • Author(s): Wataru Kakegawa, Yurika Miyoshi, Kenji Hamase, Shinji Matsuda, Keiko Matsuda, Kazuhisa Kohda, Kyoichi Emi, Junko Motohashi, Ryuichi Konno, Kiyoshi Zaitsu, Michisuke Yuzaki
  • Journal Title: Nature Neuroscience 14 Pages: 603-611
  • Peer Reviewed
• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. (2010)
  • Author(s): Keiko Matsuda, Eriko Miura, Taisuke Miyazaki, Wataru Kakegawa, Kyoichi Emi, Sakae Narumi, Yugo Fukazawa, Aya Ito-Ishida, Tetsuro Kondo, Ryuichi Shigemoto, Masahiko Watanabe, Michisuke Yuzaki
  • Journal Title: Science 328 Pages: 363-368
  • Peer Reviewed
• [Journal Article] Reevaluation of neurodegeneration in lurcher mice : constitutive ion fluxes cause cell death with, not by, autophagy. (2010)
  • Author(s): Jun Nishiyama, Keiko Matsuda, Wataru Kakegawa, Nobuaki Yamada, Junko Motohashi, Noboru Mizushima, Michisuke Yuzaki
  • Journal Title: Journal of Neuroscience 30 Pages: 2177-2187
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. (2009)
  • Author(s): Wataru Kakegawa, Taisuke Miyazaki, Kazuhisa Kohda, Keiko Matsuda, Kyoichi Emi, Junko Motohashi, Masahiko Watanabe, Michisuke Yuzaki
  • Journal Title: Journal of Neuroscience 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning.
  • Author(s): Kyoichi Emi, Kazuhisa Kohda, Wataru Kakegawa, Sakae Narumi, Michisuke Yuzaki
  • Journal Title: Neurochemical Research 印刷中
  • Peer Reviewed
• [Presentation] Endogenous D-serine controls cerebellar LTD and motor performance through GluD2. (2010)
  • Author(s): Wataru Kakegawa, Yurika Miyoshi, Kenji Hamase, Kiyoshi Zaitsu, Michisuke Yuzaki
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] Differential regulation of synapse formation and plasticity by GluRδ2 in the cerebellum. (2009)
  • Author(s): Wataru Kakegawa, Taisuke Miyazaki, Kyoichi Emi, Keiko Matsuda, Kazuhisa Kohda, Junko Motohashi, Masayoshi Mishina, Masahiko Watanabe, Michisuke Yuzaki
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Book] 生体の科学:シナプスをめぐるシグナリング(Delta2受容体) (2010)
  • Author(s): 幸田和久, 掛川渉, 柚崎通介
  • Total Pages: 382-383
  • Publisher: 医学書院
• [Remarks] ホームページ等
  • URL: http://www.yuzaki-lab.org/