2010 Fiscal Year Final Research Report
Effect of running wheel on methamphetamine abuse in mice : a possible pharmacotherapy for drug abuse by environmental enrichment
| Project/Area Number |
21790254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
KITANAKA Nobue Hyogo College of Medicine, 医学部, 講師 (30340954)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬物治療 / トキシコロジー |
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| Research Abstract |
We investigated whether environmental enrichment (i.e. exposure to a running wheel) affected methamphetamine (METH) effects, such as hyperlocomotion and abuse, in mice. Gradually increasing running wheel activity was observed over three consecutive days after exposure to a running wheel with no effects on their food or water intakes. Exposure to the running wheel did not affect METH-induced hyperlocomotion or development of abuse, but the exposure accelerated the extinction of METH abuse.
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Research Products
(11 results)
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[Journal Article] Withdrawal from fixed-dose injection of methamphetamine decreases cerebral levels of 3-methoxy-4-hydroxyphenylglycol and induces the expression of anxiety-related behavior in mice.2010
Author(s)
Kitanaka, N., Kitanaka, J., Tatsuta, T., Tanaka, K., Watabe, K., Nishiyama, N., Morita, Y., Takemura, M.
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Journal Title
Neurochem. Res. 35(5)
Pages: 749-760
Peer Reviewed
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[Journal Article] Histamine H_3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine.
Author(s)
Kitanaka, J., Kitanaka, N., Hall, F.S., Uhl, G.R., Tatsuta, T., Morita, Y., Tanaka, K., Nishiyama, N., Takemura, M.
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Journal Title
Peer Reviewed
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