2010 Fiscal Year Final Research Report
Molecular mechanisms of the formation and reduction of invadepodia
| Project/Area Number |
21790328
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
SHIRAKABE Kyoko Keio University, 医学部, 講師 (00345315)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 浸潤突起 / シェディング / podosome |
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| Research Abstract |
I have analyzed the relationship between molecular mechanisms of the formation and reduction of invadepodia, a structure permit cancer cells to have high mobility, and shedding, a processing mechanism of membrane proteins. Unfortunately, it has been indicated that there are no relationship between invadepodia and shedding in HeLa cancer cells, but I got the result indicating the relationship between podosome, a structure resembling with invadepodia, and shedding in Raw 264.7 macrophage cells.
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