2010 Fiscal Year Final Research Report
Function analysis of SGSM family in NURR1 related pathogenesis of Parkinson's disease
| Project/Area Number |
21790367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Keio University |
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Principal Investigator |
YANG Hao Keio University, 先導研究センター, 助教 (10464992)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / パーキンソン病 |
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| Research Abstract |
SGSM family proteins interact with NURR1, encoded by the pathogenic gene of Parkinson's disease, and associate with intracellular vesicular transportation. The function of SGSM family proteins was analyzed by molecular biological approaches and the results indicated that SGSM2 was localized at trans-Golgi network and involved in the clathrin-dependent vesicular transportation. The association between SGSM2 and small G protein RAB family proteins was investigated by mammalian 2-hybrid system and the results suggested that SGSM2 show certain specificity for different RAB family proteins.
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