• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Function analysis of SGSM family in NURR1 related pathogenesis of Parkinson's disease

Research Project

  • PDF
Project/Area Number 21790367
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

YANG Hao  Keio University, 先導研究センター, 助教 (10464992)

Project Period (FY) 2009 – 2010
Keywords脳・神経 / パーキンソン病
Research Abstract

SGSM family proteins interact with NURR1, encoded by the pathogenic gene of Parkinson's disease, and associate with intracellular vesicular transportation. The function of SGSM family proteins was analyzed by molecular biological approaches and the results indicated that SGSM2 was localized at trans-Golgi network and involved in the clathrin-dependent vesicular transportation. The association between SGSM2 and small G protein RAB family proteins was investigated by mammalian 2-hybrid system and the results suggested that SGSM2 show certain specificity for different RAB family proteins.

  • Research Products

    (2 results)

All 2010 2009

All Presentation (2 results)

  • [Presentation] SGSM2タンパクはRAB11と協調してクラスリンコート小胞による逆行性輸送を制御する2010

    • Author(s)
      楊浩
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      20101207-20101210
  • [Presentation] 過剰に発現させたSGSM2タンパクはクラスリンコート小胞を介する輸送システムを阻害する2009

    • Author(s)
      楊浩
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-20091212

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi