2010 Fiscal Year Final Research Report
Identification of the receptor for Bordetella dermonecrotic toxin.
| Project/Area Number |
21790417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
FUKUI Aya Osaka University, 微生物病研究所, 助教 (70397743)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ボルデテラ属細菌 / 細菌毒素 / 受容体 |
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| Research Abstract |
The aim of this project was to identify a receptor for Bordetella dermonecrotic toxin (DNT). I have determined the minimum region of DNT for cell binding, and attempted to isolate the receptor by using the synthetic peptide corresponding to the region. The functional receptor remains unknown and further trials would be needed to identify it. While attempting to purify the receptor, I found that DNT associates with the extracellular matrix. This association may facilitate the toxin action on target cells in vivo.
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