2010 Fiscal Year Final Research Report
Analysis of generation mechanism of highly pathogenic avian influenza virus
Project/Area Number |
21790451
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Virology
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
KISHIDA Noriko National Institute of Infectious Diseases, インフルエンザウイルス研究センター第1室, 研究員 (70435965)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 高病原性インフルエンザウイルス / H5 / H7 |
Research Abstract |
Influenza A viruses have two major viral surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), and 16 HA and 9 NA subtypes are recognized at present. However, highly pathogenic influenza virus for chicken appears only in H5 and the H7 sub-type. These viruses have multiple basic amino acids at the cleavage site of the HA. We searched peculiar base sequences that induce insertion of multiple basic amino acids from Gene data bank. As a result, necessary common sequences for high pathogenicity, that is, the insertion of the basic amino acid was found. Moreover, HA genes of non-pathogenic H5 and H6 viruses isolated from migratory ducks were analyzed. As a result, H5 virus had common sequences, while H6 virus had not. We will analyze the mutant viruses introduced the common sequences in the future.
|
Research Products
(19 results)
-
[Journal Article] Enzyme-linked immunosorbent assay for detection of filovirus species-specific antibodies.2010
Author(s)
Nakayama E., Yokoyama A., Miyamoto H., Igarashi M., Kishida N., Matsuno K., Marzi A., Feldmann H., Ito K., Saijo M., Takada A
-
Journal Title
Clin Vaccine Immunol. 17(11)
Pages: 1723-1728
-
[Journal Article] Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back to their northern territory.2010
Author(s)
Sakoda Y., Sugar S., Batchluun D., Erdene-Ochir T., Okamatsu M., Isoda N., Soda K., Takakuwa H., Tsuda Y., Yamamoto N., Kishida N., Matsuno K., Nakayama E., Kajihara M., Yokoyama A., Takada A., Sodnomdarjaa R., Kida H
-
Journal Title
Virology. 10;406(1)
Pages: 88-94
-
[Journal Article] Working Group for Influenza Virus Surveillance in Japan. Oseltamivir-resistant influenza viruses A (H1N1) during 2007-2009 influenza seasons, Japan.2010
Author(s)
Ujike M., Shimabukuro K., Mochizuki K., Obuchi M., Kageyama T., Shirakura M., Kishida N., Yamashita K., Horikawa H., Kato Y., Fujita N., Tashiro M., Odagiri T
-
Journal Title
Emerg Infect Dis. Jun 16(6)
Pages: 926-935
-
[Journal Article] Molecular Evolutionary Analysis of the Influenza A(H1N1)pdm,Temporal andSpatial Spreading Profile of the Viruses in Japan.2010
Author(s)
Shiino T., Okabe N., Yasui Y., Sunagawa T., Ujike M., Obuchi M., Kishida N., Xu H., Takashita E., Anraku A., Ito R., Doi T., Ejima M., Sugawara H., Horikawa H., Yamazaki S., Kato Y., Oguchi A., Fujita N., Odagiri T., Tashiro M., Watanabe H
-
Journal Title
-
[Journal Article] Different potential of C-type lectin-mediated entry between Marburg virus strains.2010
Author(s)
Matsuno K., Kishida N., Usami K., Igarashi M., Yoshida R., Nakayama E., Shimojima M., Feldmann H, Irimura T, Kawaoka Y, Takada A
-
Journal Title
J Virol. 84(10)
Pages: 5140-5147
-
[Journal Article] Influenza Virus Surveillance Group of Japan.Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus2009
Author(s)
Ujike M, Ejima M, Anraku A, Shimabukuro K, Obuchi M, Kishida N, Hong X, Takashita E, Fujisaki S, Yamashita K, Horikawa H, Kato Y, Oguchi A, Fujita N, Tashiro M, Odagiri T
-
Journal Title
Japan, Emerg Infect Dis. 2011 Mar 17(3)
Pages: 470-479
-
-
-
-
[Journal Article] Potency of an inactivated avian influenza vaccine prepared from a reassortant non-pathogenic H5N1 virus generated between isolates from migratory ducks in Asia.2008
Author(s)
Isoda N., Sakoda Y., Kishida N., Soda K., Sakabe S., Sakamoto R., Imamura T., Skaguchi M., Sasaki T., Kokumai N., Ohgitani T., Sijo K., Sawata A., Hagiwara J., Lin Z., Kida H.
-
Journal Title
Archives of Virology 153
Pages: 1685-1692
-
[Journal Article] Phylogenic analysis of the M gene of influenza viruses isolated from free-flying water birds from their Northern territory to Hokkaido, Japan.2008
Author(s)
Manzoor R., Sakoda Y., Mweene A., Tsuda Y., Kishida N., Bai G., R., Kameyama K., Isoda N., Soda K., Naito M., Kida H
-
Journal Title
Virus Genes 37
Pages: 144-152
-
-
-
-
-
-
-
-
[Remarks] ホームページ等