2010 Fiscal Year Final Research Report
Research of biological function and distinctive role of Sirp・^+ dendritic cells in central tolerance
| Project/Area Number |
21790464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kanazawa University |
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Principal Investigator |
BABA Tomohisa Kanazawa University, がん研究所, 助教 (00452095)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 胸腺 / 樹状細胞 / 免疫寛容 |
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| Research Abstract |
In this study, we investigated the mechanism of differentiation, intrathymic localization, and distinctive function of Sirp・^<・・>tDCs in central tolerance. Our observation revealed that Sirp・^<・・> tDCs were disseminated in the thymic cortical area, with some of them uniquely localized inside PVRs. Moreover, Sirp・^<・・> cDC subset can selectively capture blood-borne antigens under the multi-step guidance of CCR2-mediated signals. Furthermore, they can present blood-borne antigens to the majority of immature thymocytes to induce antigen-specific Treg generation.
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