2011 Fiscal Year Final Research Report
Elucidation of mechanisms regulating impulsivity in the developmental disorders and its pharmacotherapy : From a viewpoint of brain reward system
| Project/Area Number |
21790515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagasaki International University (2010-2011)
Hokkaido University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発達障害 / 注意欠如多動性障害 / 衝動性 / SHRSP/Ezo / SHR亜系 / 行動解析 / 網羅的一塩基遺伝子多型解析 / 幼若期ストレス / 薬物治療 |
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| Research Abstract |
In this study, to elucidate the mechanisms regulating impulsivity in the developmental disorders, I mainly explored the key neuronal molecules related to the expression/formation of impulsive behaviors in model rats of developmental disorder. I investigated using the juvenile stroke-prone spontaneous hypertensive rat (SHRSP/Ezo: Ezo) as an appropriate animal model of "attention deficit hyperactivity disorder (ADHD)" and we also used juvenile SHRSP/Izm (Izm) and SHRSP/Ngsk (Ngsk) which are similar to genetic background of Ezo in the SHR substrain. In comparison with juvenile WKY/Ezo which is a genetic control for Ezo, impulsive behavior in the elevated plus-maze test only observed in the Ezo, but not Izm and Ngsk, which behavioral properties were specific for Ezo. Base on the behavioral result, I explored the polymorphic regions linked Ezo-specific behavior differ from that of Izm and Ngsk using the database determined by global analysis of single nucleotide polymorphism (SNP). 137 SNPs linked Ezo-specific behavior were identified in the 21,032 candidate genes based on SNPs of Brown Norway rat. These SNPs linked Ezo-specific behavior were retained on the chromosome 7, 9 and X-chromosome. These findings suggested that genetic background associated with impulsive behavior in the Ezo as an ADHD model rat was related to the SNPs on the chromosome 7, 9 and X-chromosome and functional molecules linked to the development and formation of neuronal cells.
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[Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats2011
Author(s)
Matsuzaki H, Izumi T, Horinouchi T, Boku S, Inoue T, Yamaguchi T, Yoshida T, Matsumoto M, Togashi H, Miwa S, Koyama T, Yoshioka M
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Journal Title
Psychopharmacology (Berl)
Volume: 214
Pages: 329-337
DOI
Peer Reviewed
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[Journal Article] Serotonin1A receptormadiated synaptic responses in the rat medial prefrontal cortex is altered by early life stress: In vivo and in vitro electrophysiological studies2011
Author(s)
Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A, Ishikawa S, Yamaguchi T, Yoshioka M, Shimamura K.
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Journal Title
Jpn J Neuropsychopharmacol
Volume: 31
Pages: 9-15
URL
Peer Reviewed
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[Journal Article] Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala2011
Author(s)
Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M.
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Journal Title
J Neurosci Res.
Volume: 89
Pages: 773-790
DOI
Peer Reviewed
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