2011 Fiscal Year Final Research Report

Association of genetic polymorphisms in human NR1I3 with the diseases in elderly Japanese population.

Research Project

Project/Area Number	21790549
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Tokyo Medical and Dental University
Principal Investigator	IKEDA Shinobu 東京医科歯科大学, 難治疾患研究所, 助教 (20415508)
Project Period (FY)	2009 – 2011
Keywords	分子遺伝疫学・フェノームスキャン研究
Research Abstract	In this study, we performed search for genotype-phenotype associations in consecutive autopsies of elderly Japanese population, focusing on human CAR polymorphisms and various diseases. We found that several SNPs in NR1I3 gene were significantly associated with reduce or increase risk of the diseases, after adjustment. We provide data that polymorphisms of CAR, which controls the metabolism and elimination of endogenous and exogenous toxic compound or drugs, may play an important role in the development of the diseases. However, further prospective studies with large sample sizes are required to confirm our observations.

(4 results)