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2010 Fiscal Year Final Research Report

Molecular mechanisms of ethanol dependence and relapse-role in the brain microRNA

Research Project

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Project/Area Number 21790611
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionSapporo Medical University

Principal Investigator

MIZUO Keisuke  Sapporo Medical University, 医学部, 助教 (90459735)

Project Period (FY) 2009 – 2010
Keywordsアルコール / マイクロRNA / 依存
Research Abstract

Prolonged ethanol intake leads to the development of ethanol dependence. Although a lot of study suggested several candidates, certain mechanism of ethanol action is still unclear. Here we show that acute ethanol administration increased the expression of microRNA in mouse brain at 12 hours after administration. We observed that the acute ethanol administration significantly increased the levels of acetylated histone H3 in nucleus accumbens, ventral tegmental area and amygdala. The expression of miR-124 was significantly increased in limbic forebrain and lower midbrain following chronic treatment of ethanol. These findings suggest that chronic ethanol consumption increase the microRNA expression via histone acetylation, resulting in development of ethanol dependence.

  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (2 results) Presentation (8 results)

  • [Journal Article] Effect of acute ethanol administration on histone deacetylases in mouse brain.2011

    • Author(s)
      Mizuo.K., Katada, R., Tateda, K., Okazaki, S., Watanabe, S., Matsumoto, T.
    • Journal Title

      Alcohol Biomed.Res. In press

  • [Journal Article] Expression of miR-132 in murine brain after acute ethanol administration.2010

    • Author(s)
      Mizuo.K., Nishitani, Y., Katada, R., Tateda, K., Okazaki, S., Watanabe, S., Matsumoto, T.
    • Journal Title

      Alcohol Biomed.Res. 29

      Pages: 52-54

  • [Presentation] アルコールの急性投与は脳におけるmicroRNA発現に影響を及ぼすか2010

    • Author(s)
      水尾圭祐
    • Organizer
      包括脳ネットワーク
    • Place of Presentation
      ホテルさっぽろ芸文館(札幌市)
    • Year and Date
      20100728-20100729
  • [Presentation] エタノール急性投与が脳におけるヒストン脱アセチル化酵素に及ぼす影響2010

    • Author(s)
      水尾圭祐
    • Organizer
      アルコール医学生物学研究会
    • Place of Presentation
      久留米翠香園ホテル(久留米市)
    • Year and Date
      2010-11-26
  • [Presentation] エタノール急性投与は脳におけるヒストンアセチル化を促進する2010

    • Author(s)
      水尾圭祐
    • Organizer
      日本アルコール・薬物医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(小倉市)
    • Year and Date
      2010-10-09
  • [Presentation] Acute ethanol admi nistration changes in the expression of microRNAs in mouse brain.2010

    • Author(s)
      Keisuke Mizuo
    • Organizer
      International Society for Biomedical Research on Alcoholism
    • Place of Presentation
      CAPS15(パリ市)
    • Year and Date
      2010-09-16
  • [Presentation] エタノール急性投与が脳におけるヒストンアセチル化に及ぼす影響2010

    • Author(s)
      水尾圭祐
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2010-09-04
  • [Presentation] エタノールの急性投与は脳におけるmiR-124の発現を増加させる2010

    • Author(s)
      水尾圭祐
    • Organizer
      日本法医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-06-24
  • [Presentation] アルコールによる中枢神経系におけるmiR-132の発現動態2009

    • Author(s)
      水尾圭祐
    • Organizer
      アルコール医学生物学研究会
    • Place of Presentation
      三井ガーデンホテル千葉(千葉市)
    • Year and Date
      2009-11-13
  • [Presentation] エタノール急性投与による脳におけるマイクロRNAの発現変動2009

    • Author(s)
      水尾圭祐
    • Organizer
      日本アルコール・薬物医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-09-09

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Published: 2012-02-13   Modified: 2016-04-21  

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