2010 Fiscal Year Final Research Report
Analyses on the acceleration mechanism of vascular dementia by chronic stress
| Project/Area Number |
21790639
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Institute for Longevity Sciences,NCGG |
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Principal Investigator |
KUNIMOTO Shohko 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 流動研究員 (30350135)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ストレス / 脳血管性認知症 / CADASIL / 動物モデル |
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| Research Abstract |
CADASIL is the most common hereditary small vessel disease that is characterized by recurrent subcortical ischemic strokes and ultimately vascular dementia. It is linked to dominant mutations in the human NOTCH3 gene, which is primarily expressed in vascular smooth muscle cells (VSMCs) of the vessel wall. Pathogenic mechanisms remain unclear by the lack of a good animal model. Here, we generated a knock-in (KI) mouse model for one of the CADASIL mutations and investigated this mouse to elucidate whether the pathological hallmarks of CADASIL are observed with mutant Notch3. Further, we examined the effect of chronic intermittent restraint stress on the pathogenesis of CADASIL using this mouse.
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