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2010 Fiscal Year Final Research Report

A comprehensive analysis of pancreatitis associated CNVs to establish a screening method

Research Project

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Project/Area Number 21790646
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KUME Kiyoshi  Tohoku University, 大学院・医学系研究科, 非常勤講師 (30431563)

Project Period (FY) 2009 – 2010
Keywords膵炎 / 遺伝子異常
Research Abstract

The aim of this study was to investigate the association of trypsinogen copy number mutations with pancreatitis in Japan. None of 230 Japanese patients with chronic pancreatitis and 180 patients with acute pancreatitis had this mutation. This copy number mutation might be rare in Japan.

  • Research Products

    (21 results)

All 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Genetic background is different between sentinel and recurrent acute pancreatitis.2011

    • Author(s)
      正宗淳、有賀啓之、粂潔, ほか4名
    • Journal Title

      J Gastroenterol Hepatol. 印刷中

    • Peer Reviewed
  • [Journal Article] -651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan.2010

    • Author(s)
      正宗淳、粂潔、菊田和宏, ほか8名
    • Journal Title

      J Gastroenterol. 45巻

      Pages: 225-233

    • Peer Reviewed
  • [Journal Article] 遺伝子異常と膵炎の発症2010

    • Author(s)
      粂潔、下瀬川徹
    • Journal Title

      HUMAN SCIENCE 21巻

      Pages: 22-25

  • [Journal Article] 慢性膵炎と膵癌2010

    • Author(s)
      粂潔、正宗淳、菅野敦, ほか7名
    • Journal Title

      肝胆膵画像 12巻

      Pages: 215-222

  • [Journal Article] 家族性膵疾患とそのアプローチ2010

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      成人病と生活習慣病 40巻

      Pages: 69-73

  • [Journal Article] Microsatellite polymorphism in intron 2 of human Toll-like recept or 2 gene is associated with susceptibility to acute pancreatitis in Japan.2009

    • Author(s)
      高木康彦、正宗淳、粂潔, ほか6名
    • Journal Title

      Hum Immunol 70巻

      Pages: 200-204

    • Peer Reviewed
  • [Journal Article] A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders.2009

    • Author(s)
      粂潔、正宗淳、高木康彦, ほか7名
    • Journal Title

      GUT 58巻

      Pages: 820-824

    • Peer Reviewed
  • [Journal Article] 膵癌危険因子としてのSPINK1遺伝子変異2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      消化器科 49巻

      Pages: 533-537

  • [Journal Article] 膵癌危険因子としてのSPINK1遺伝子変異2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      THE GIFOREFRONT 5巻

      Pages: 89-91

  • [Journal Article] 遺伝子異常は膵炎とどうかかわるのか2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      分子消化器病 6巻

      Pages: 219-225

  • [Journal Article] 急性膵炎と修飾する遺伝子異常2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      肝・胆・膵 59

      Pages: 173-179

  • [Journal Article] 成因別特徴(膵石症の頻度・分布)遺伝性膵炎2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      肝・胆・膵 58巻

      Pages: 467-475

  • [Journal Article] 膵臓疾患の分子機構2009

    • Author(s)
      下瀬川徹、粂潔、濱田晋
    • Journal Title

      臨床消化器内科 24巻

      Pages: 239-238

  • [Presentation] Measurement of serum PSTI level might be useful to detect IVS3+2T>C (c.194+2T>C) mutation in the SPINK1 gene2010

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      United European Gastroenterology Week
    • Place of Presentation
      Barcelona、Spain
    • Year and Date
      2010-10-26
  • [Presentation] 膵炎リスクとしてのアルコールと遺伝的要因2010

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      日本アルコール・薬物医学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-08
  • [Presentation] Genetic background of chronic pancreatitis in Japan2010

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      国際膵臓学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-07-13
  • [Presentation] Chymotrypsin C gene variations in Japanese patients with Chronic Pancreatitis2010

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      国際膵臓学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-07-12
  • [Presentation] 慢性膵炎における遺伝子異常2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      日本膵臓学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-31
  • [Book] 遺伝子変異による機能異常と膵炎(第94回日本消化器病学会総会記念誌)2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Total Pages
      61-64
    • Publisher
      財団法人日本消化器病学会
  • [Book] Annual Review 2009消化器2009

    • Author(s)
      粂潔
    • Total Pages
      239-244
    • Publisher
      中外医学社
  • [Remarks] ホームページ等

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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