2010 Fiscal Year Final Research Report
Analysis of adiponectin and drugs improving insulin resistance in colorectal carcinogenesis
| Project/Area Number |
21790679
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TAKAHASHI Hirokazu Yokohama City University, 附属病院, 助教 (70438159)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 大腸癌 / アディポネクチン / ACF / PPARγ / metformin |
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| Research Abstract |
Obesity and its associated visceral fat accumulation have been reported to be linked to an elevated risk of cardiovascular disease, diabetes mellitus, and mortality, and these complications are rapidly becoming significant problems. Visceral adipose tissue is not only fat storage tissue, but also a metabolically active organ secreting many adipocytokines, such as adiponectin. Obesity is reportedly an important risk factor for CRC. Adiponectin and drugs improving insulin resistance for inhibiting colorectal carcinogenesis in mouse model and humans provides preliminary evidence, suggesting its promise for the chemoprevention of colorectal cancer. Further studies should be conducted to clarify the role that visceral fat accumulation and reduced plasma adiponectin play in obesity-related CRC prevention.
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[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis.2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
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Journal Title
Gut. [Epub ahead of print]
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[Journal Article] Leptin receptor is involved in STAT3 activation in human colorectal adenoma.2010
Author(s)
Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Endo H, Hosono K, Yoneda K, Yoneda M, Inamori M, Nagashima Y, Inayama Y, Wada K, Nakajima A.
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Journal Title
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[Journal Article] Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial.2010
Author(s)
Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, Koide T, Tokoro C, Abe Y, Inamori M, Nakagama H, Nakajima A.
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Journal Title
Cancer Prev Res. 3
Pages: 1077-1083
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[Journal Article] Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.2010
Author(s)
Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A.
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Journal Title
Mol Carcinog. 49
Pages: 662-671
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[Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition.2009
Author(s)
Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
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Journal Title
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[Journal Article] Identification of Cystatin SN as a novel tumor marker for colorectal cancer.2009
Author(s)
Yoneda K, Iida H, Endo H, Hosono K, Akiyama T, Takahashi H, Inamori M, Abe Y, Yoneda M, Fujita K, Kato S, Nozaki Y, Ichikawa Y, Uozaki H, Fukayama M, Shimamura T, Kodama T, Aburatani H, Miyazawa C, Ishii K, Hosomi N, Sagara M, Takahashi M, Ike H, Saito H, Kusakabe A, Nakajima A.
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Journal Title
Int J Oncol. 35
Pages: 33-40
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[Journal Article] Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals.2009
Author(s)
Takahashi H, Takayama T, Hosono K, Yoneda K, Endo H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakagama H, Nakajima A.
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Journal Title
Mol Med Report. 2
Pages: 339-343
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[Journal Article] Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway.2009
Author(s)
Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Int J Oncol. 34
Pages: 339-344
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[Presentation] Analysis of human aberrant crypt foci after colorectal polypectomy2010
Author(s)
Takahashi H, Sakai E, Sugiyama M, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Koide T, Tokoro C, Inamori M, Abe Y, Maeda S, Nakajima A
Organizer
2010 18^<th> UEGW poster session
Place of Presentation
Barcelona
Year and Date
2010-10-27
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[Presentation] Critical role of leptin in the regulation of colorectal tumor growth through Stat3 signaling : Tumor growth induced by dietary intake2010
Author(s)
Endo H, Hosono K, Uchiyama T, Iida H, Fujita K, Takahashi H, Yoneda M, Inamori M, Kirikoshi H, Kubota K, Nakajima A
Organizer
Digestive Disease Week 2010 Poster Session
Place of Presentation
New Orleans
Year and Date
2010-05-02
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[Presentation] 大腸腫瘍進展における糖尿病関連因子の相関解析2010
Author(s)
高橋宏和, 細野邦広, 内山崇, 飯田洋, 遠藤宏樹, 野崎雄一, 坂本康成, 藤田浩司, 米田正人, 古出智子, 所知加子, 後藤歩, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
Organizer
第96回日本消化器病学会総会 ポスター
Place of Presentation
新潟
Year and Date
2010-04-22
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[Presentation] Plasma IGF-1 Is Correlated with Dysplastic Aberrant Crypt Foci in Men.2009
Author(s)
Takahashi H, Hosono K, Endo H, Yoneda K, Akiyama T, Inamori M, Abe Y, Kato S, Uchiyama T, Iida H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
Organizer
Digestive Disease Week 2009 AGA Institute Poster Session
Place of Presentation
Chicago
Year and Date
2009-06-03
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[Presentation] 大腸その他3 Aberrant crypt fociの自然史に対する解析2009
Author(s)
高橋宏和, 細野邦広, 遠藤宏樹, 米田恭子, 加藤真吾, 内山崇, 飯田洋, 馬渡弘典, 野崎雄一, 秋山智之, 藤田浩司, 米田正人, 稲森正彦, 阿部泰伸, 小林規俊, 桐越博之, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
Organizer
第77回日本消化器内視鏡学会総会
Place of Presentation
名古屋(一般口演)
Year and Date
2009-05-21
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[Presentation] Natural history of human aberrant crypt foci after colorectal polypectomy2009
Author(s)
Takahashi H, Hosono K, Endo H, Yoneda K, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
Organizer
100^<th> AACR Annual Meeting 2009
Place of Presentation
Denver
Year and Date
2009-04-19
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