2010 Fiscal Year Final Research Report
The regulatory mechanism for the control of atherosclerotic lesion formation by arterial adventitia and perivascular tissues
| Project/Area Number |
21790707
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Kimie The University of Tokyo, 医学部附属病院, 特任助教 (30508065)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 動脈硬化 / 血管外膜 / vasa vasorum / 血管周囲組織 / 脂肪組織 / 血管新生因子動脈硬化モデルマウス / bFGF |
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| Research Abstract |
The vasa vasorum (VV) are the microvasculature present in the adventitial layer of the atherosclerotic vessel wall, which are surrounded by perivascular tissues like adipose tissues. However, it remains unclear whether these perivascular structures affect to atherosclerotic lesion formation and progression. In this study, using a hypercholesterolemic mouse model, the relationship between atherosclerotic lesions and adventitial VV and perivascular tissues were evaluated. The clear histological imaging method of microvessels was also developed.
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