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2010 Fiscal Year Final Research Report

The role of CCN family signaling in pulmonary fibrosis, and CCN pathway may be an effective molecular therapeutic strategy for fibrotic lung disease

Research Project

  • PDF
Project/Area Number 21790772
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

AZUMA Momoyo  The University of Tokushima, 病院, 特任助教 (10403750)

Project Period (FY) 2009 – 2010
Keywords肺線維症 / CCNインテグリン / FAK
Research Abstract

Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin……Furthermore, CCN6 showed ability to stimulate the expression of fibronectin. Our results suggest that CCN6 is a potential target for the treatment of pulmonary fibrosis.

  • Research Products

    (7 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 間質性肺炎の治療法の展開2010

    • Author(s)
      西岡安彦、東桃代
    • Journal Title

      イマチニブ Vol58

      Pages: 389-395

  • [Journal Article] 線維化病変に対するイマチニブの効果2009

    • Author(s)
      西岡安彦、東桃代
    • Journal Title

      血液・腫瘍科 Vol59

      Pages: 181-188

  • [Journal Article] Blockade of Th1 chemokine receptors ameriolates pulmonary granulomatosis in mice.

    • Author(s)
      Kishi, J., Nishioka,Y., Azuma,M.
    • Journal Title

      Eur Respir J in press

    • Peer Reviewed
  • [Presentation] Effects of the novel immunomodulator sphingosine 1-phospate(SIP) receptor agonist FTY720 in bleomycin-induced pulmonary fibrosis in mice.2010

    • Author(s)
      Nishioka,Y., Azuma,M.
    • Organizer
      American Thoracic
    • Place of Presentation
      Society, USA
    • Year and Date
      2010-05-19
  • [Presentation] 新規免疫抑制薬フィンゴリモド(FTY720)のマウスブレオマイシン誘発肺線維症に及ぼす効果の検討2010

    • Author(s)
      東桃代
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-03
  • [Book] 厚生労働科学研究 難治性疾患克服研究事業 びまん性肺疾患に関する調査研究班2008

    • Author(s)
      西岡安彦、東桃代
    • Publisher
      報告書
  • [Remarks] ホームページ等

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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