2010 Fiscal Year Final Research Report
Detection of anti-erythropoietin receptor autoantibodies in patients with anemia of chronic disease
| Project/Area Number |
21790803
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
HARA Akinori Kanazawa University, 附属病院, 特任助教 (70507045)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 蛋白質 / トランスレーショナルリサーチ / 内科 / 免疫学 / 臨床 |
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| Research Abstract |
We examined the prevalence, clinical associations and pathogenic role of novel autoantibodies to the erythropoietin receptor (EPOR) in patients with anemia of chronic disease (ACD). As a result, serum anti-EPOR antibodies were detected in some patients, but in none of the healthy controls. Sera from patients with anti-EPOR antibodies inhibited EPO-dependent cell proliferation. Among SLE patients studied, anti-EPOR antibodies were associated with reticulocytopenia and a decrease in bone marrow erythroblasts. In conclusion, impaired erythropoiesis may be mediated by anti-EPOR antibodies, which functionally neutralize EPO activity.
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Research Products
(5 results)
