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2010 Fiscal Year Final Research Report

Detection of anti-erythropoietin receptor autoantibodies in patients with anemia of chronic disease

Research Project

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Project/Area Number 21790803
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKanazawa University

Principal Investigator

HARA Akinori  Kanazawa University, 附属病院, 特任助教 (70507045)

Project Period (FY) 2009 – 2010
Keywords蛋白質 / トランスレーショナルリサーチ / 内科 / 免疫学 / 臨床
Research Abstract

We examined the prevalence, clinical associations and pathogenic role of novel autoantibodies to the erythropoietin receptor (EPOR) in patients with anemia of chronic disease (ACD). As a result, serum anti-EPOR antibodies were detected in some patients, but in none of the healthy controls. Sera from patients with anti-EPOR antibodies inhibited EPO-dependent cell proliferation. Among SLE patients studied, anti-EPOR antibodies were associated with reticulocytopenia and a decrease in bone marrow erythroblasts. In conclusion, impaired erythropoiesis may be mediated by anti-EPOR antibodies, which functionally neutralize EPO activity.

Research Products

(5 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Detection of autoantibodies to erythropoietin-erythropoietin receptor system in patients with anemia of chronic disease.2009

    • Author(s)
      Hara A, Furuichi K, Yamauchi H, Kitagawa K, Sakai N, Higuchi M, Kaneko S, Wada T.
    • Journal Title

      J Am Soc Nephrol(Abstract) 20

      Pages: 309A

    • Peer Reviewed
  • [Presentation] Detection of autoantibodies to erythropoietin-erythropoietin receptor system in patients with anemia of chronic disease.2009

    • Author(s)
      Hara A, Hiroyuki Yamauchi, Kiyoki Kitagawa, Norihiko Sakai, Kengo Furuichi, Masato Higuchi, Shuichi Kaneko, Takashi Wada.
    • Organizer
      ASN Renal Week 2009
    • Place of Presentation
      San Diego Convention Center (USA)
    • Year and Date
      2009-10-29
  • [Presentation] エリスロポエチン-エリスロポエチン受容体相互作用に関与する抗体の検出とその臨床的意義の検討2009

    • Author(s)
      原章規, 和田隆志
    • Organizer
      第49回日本臨床化学会年次学術集会
    • Place of Presentation
      長崎大学医学部(長崎県)
    • Year and Date
      2009-09-20
  • [Presentation] 貧血の新規機序としての抗エリスロポエチン受容体抗体の同定とその基礎的・臨床的特性の解析2009

    • Author(s)
      原章規, 古市賢吾, 和田隆志
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2009-08-27
  • [Book] 第18回腎とエリスロポエチン研究会Proceedings2010

    • Author(s)
      原章規, 山内博之, 北川清樹, 坂井宣彦, 古市賢吾, 樋口正人, 和田隆志
    • Total Pages
      93-94
    • Publisher
      ライフサイエンス出版

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Published: 2012-02-12   Modified: 2016-04-21  

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